Concepedia

Endocervical and Neutrophil Lipoxygenases Coordinate Neutrophil Transepithelial Migration to Neisseria gonorrhoeae

Jacqueline S. Stevens, Mary C. Gray, Christophe Morisseau, Alison K. Criss

The Journal of Infectious Diseases · 2018 · 16 citations · 36 references

DOIFull text

Open access

Abstract

Our data support a model in which GC-endocervical cell contact infection stimulates HXA3 production, driving neutrophil migration that is amplified by neutrophil-derived LTB4. Therapeutic targeting of these pathways could limit inflammation and deleterious clinical sequelae in women with gonorrhea.

References

36

Antimicrobial resistance in Neisseria gonorrhoeae: Global surveillance and a call for international collaborative action

Teodora Wi, Monica M Lahra, Francis Ndowa et al. · PLoS Medicine · 2017 · 605 citations · Full text

Neutrophil migration across a cultured intestinal epithelium. Dependence on a CD11b/CD18-mediated event and enhanced efficiency in physiological direction.

Charles A. Parkos, C Delp, M. Amin Arnaout et al. · Journal of Clinical Investigation · 1991 · 345 citations · Full text

, , +20

Single protein from human leukocytes possesses 5-lipoxygenase and leukotriene A4 synthase activities.

Carol A. Rouzer, Takashi Matsumoto, B Samuelsson · Proceedings of the National Academy of Sciences · 1986 · 309 citations · Full text

, , +18

Generation of Papillomavirus-Immortalized Cell Lines from Normal Human Ectocervical, Endocervical, and Vaginal Epithelium that Maintain Expression of Tissue-Specific Differentiation Proteins1

Raina N. Fichorova, James G. Rheinwald, Deborah J. Anderson · Biology of Reproduction · 1997 · 305 citations · Full text

, , +21

Surface attachment of Salmonella typhimurium to intestinal epithelia imprints the subepithelial matrix with gradients chemotactic for neutrophils.

Beth A. McCormick, Paul Hofman, John Kim et al. · The Journal of Cell Biology · 1995 · 234 citations · Full text

, , +20