Neutrophil migration across a cultured intestinal epithelium. Dependence on a CD11b/CD18-mediated event and enhanced efficiency in physiological direction.

Charles A. Parkos, C Delp, M. Amin Arnaout, +1

Journal of Clinical Investigation

Physiological DirectionCell AdhesionInnate Immune SystemImmunologyPathology +18

5'-adenosine monophosphate is the neutrophil-derived paracrine factor that elicits chloride secretion from T84 intestinal epithelial cell monolayers.

James Madara, Thomas W. Patapoff, Beth L. Gillece-Castro, +4

Journal of Clinical Investigation

Intestinal epithelial restitution. Characterization of a cell culture model and mapping of cytoskeletal elements in migrating cells.

Asma Nusrat, C Delp, J L Madara

Journal of Clinical Investigation

Tissue EngineeringEngineeringCell AdhesionCell CultureCytoskeleton +20

Neutrophil migration across cultured intestinal epithelial monolayers is modulated by epithelial exposure to IFN-gamma in a highly polarized fashion.

Sean P. Colgan, Charles A. Parkos, C Delp, +2

The Journal of Cell Biology

Ifn-gamma ExposurePolarized FashionImmunologyPathologyTransepithelial Migration +15

Mechanism of cholera toxin action on a polarized human intestinal epithelial cell line: role of vesicular traffic

C Delp, MR Neutra, J L Madara

The Journal of Cell Biology

Protein SecretionVesicular TrafficGastroenterologyCytoskeletonDigestive Tract +15

Neutrophil migration across a cultured epithelial monolayer elicits a biphasic resistance response representing sequential effects on transcellular and paracellular pathways

CA Parkos, SP Colgan, C Delp, +2

The Journal of Cell Biology

Cell AdhesionBiphasic Resistance ResponseImmunologyPathologyChloride Secretion +20

A simple approach to measurement of electrical parameters of cultured epithelial monolayers: Use in assessing neutrophil-epithelial interactions

James Madara, Sean P. Colgan, Asma Nusrat, +2

Methods in Cell Science

GranulocyteElectrical ParametersIn Vivo SystemBioanalysisOrgan-on-a-chip +9

Stabilization of F-actin prevents cAMP-elicited Cl- secretion in T84 cells.

Marc J. Shapiro, Jeffrey B. Matthews, Gail Hecht, +2

Journal of Clinical Investigation

Protein SecretionCell AdhesionImmunologyCytoskeletonCl- Secretion +18

Cl- secretion in a model intestinal epithelium induced by a neutrophil-derived secretagogue.

James Madara, Charles A. Parkos, Sean P. Colgan, +5

Journal of Clinical Investigation

Protein SecretionImmunologyImmune RegulationPathologyGastroenterology +22

In vitro model of intestinal crypt abscess. A novel neutrophil-derived secretagogue activity.

S Nash, Charles A. Parkos, Asma Nusrat, +2

Journal of Clinical Investigation

InflammationAllergyMucosal ImmunologyGranulocyteVitro Model +13