Concepedia

The effect of volanesorsen treatment on the burden associated with familial chylomicronemia syndrome: the results of the ReFOCUS study

Marcello Arca, Andrew Hsieh, Handrean Soran, Paul D. Rosenblit, Louis O’Dea, Michael Stevenson

Expert Review of Cardiovascular Therapy · 2018 · 43 citations · 13 references

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Abstract

Treatment with volanesorsen has the potential to reduce disease burden in patients with FCS through modulation of multiple symptom domains.

References

13

ESC/EAS Guidelines for the management of dyslipidaemias: The Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS)

European Heart Journal · 2011 · 3.5K citations · Full text

Targeting APOC3 in the Familial Chylomicronemia Syndrome

Daniel Gaudet, Diane Brisson, Karine Tremblay et al. · New England Journal of Medicine · 2014 · 477 citations · Full text

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Antisense Oligonucleotide Inhibition of Apolipoprotein C-III Reduces Plasma Triglycerides in Rodents, Nonhuman Primates, and Humans

Mark J. Graham, Richard Lee, Thomas A. Bell et al. · Circulation Research · 2013 · 364 citations · Full text

Elevated Serum Triglycerides are Independently Associated With Persistent Organ Failure in Acute Pancreatitis

Haq Nawaz, Efstratios Koutroumpakis, Jeffrey J. Easler et al. · The American Journal of Gastroenterology · 2015 · 286 citations

Diagnostic algorithm for familial chylomicronemia syndrome

Erik S.G. Stroes, Philippe Moulin, Klaus G. Parhofer et al. · Atherosclerosis Supplements · 2016 · 128 citations · Full text