Nanoparticles as antiviral agents against adenoviruses

TLDR

The antiviral activity of gold nanoparticle complexes against adenovirus is valuable due to their low toxicity. The study examined both antiviral and virucidal effects of the nanoparticles and investigated how activity varies with concentration. Two shell‑coated gold nanoparticles on a carrier were synthesized; both exhibited antiviral activity and displayed a nonmonotonic dependence on concentration.

Abstract

Two types of gold nanoparticles, covered with shell and located on the large nanoparticle-carrier, have been synthesized and used as antiviral agents against adenoviruses. Both antiviral effect and virucidal action of the nanoparticles have been studied. It has been shown that both types of nanoparticles demonstrate antiviral action. Dependence of antiviral activity of nanoparticles on their concentration has been studied. Nonmonotonic dependence of the antiviral effect on nanoparticles concentration has been observed and discussed. The antiviral action of complex nanoparticles against adenovirus is important because of low toxicity of the gold nanoparticles covered with shell and of carrier nanoparticles.