Concepedia

Urate inhibits microglia activation to protect neurons in an LPS-induced model of Parkinson’s disease

Li-Hui Bao, Yanan Zhang, Jian-Nan Zhang, Li Gu, Huimin Yang, Yiying Huang, Ning Xia, Hong Zhang

Journal of Neuroinflammation · 2018 · 58 citations · 53 references

DOIFull text

Open access

Abstract

Urate protects neurons against cytotoxicity induced by microglia activation via modulating urate transporter-mediated intracellular urate level.

References

53

Neurotoxic reactive astrocytes are induced by activated microglia

Shane A. Liddelow, Kevin A. Guttenplan, Laura Clarke et al. · Nature · 2017 · 7.6K citations · Full text

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Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease

Timothy R. Sampson, Justine W. Debelius, Taren Thron et al. · Cell · 2016 · 3.4K citations · Full text

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An environment-dependent transcriptional network specifies human microglia identity

David Gosselin, Dylan Skola, Nicole G. Coufal et al. · Science · 2017 · 1.3K citations · Full text

Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway

Seija Lehnardt, Leon J. Massillon, Pamela L. Follett et al. · Proceedings of the National Academy of Sciences · 2003 · 1K citations · Full text

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Microglial Activation and Chronic Neurodegeneration

Melinda E. Lull, Michelle L. Block · Neurotherapeutics · 2010 · 1K citations · Full text