Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway

Seija Lehnardt, Leon J. Massillon, Pamela L. Follett, +5

Proceedings of the National Academy of Sciences

InflammationToll-like ReceptorsNeurodegenerative DiseasesCns TriggersMedicine +13

An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration

Sabrina Lehmann, Christina Krüger, Boyoun Park, +22

Nature Neuroscience

InflammationToll-like ReceptorsMedicineImmunologyRna Biology +8

The Toll-Like Receptor TLR4 Is Necessary for Lipopolysaccharide-Induced Oligodendrocyte Injury in the CNS

Seija Lehnardt, Christian Lachance, Silvia Patrizi, +6

Journal of Neuroscience

Microbial PathogensInnate Immune SystemImmunologyCell DeathInnate Immunity +15

Gliomas induce and exploit microglial MT1-MMP expression for tumor expansion

D. Marković, Katyayni Vinnakota, Sridhar Reddy Chirasani, +13

Proceedings of the National Academy of Sciences

Neuro-oncologyGliomaMedicineGlioma CellsImmunology +13

In Vivo Imaging of Partially Reversible Th17 Cell-Induced Neuronal Dysfunction in the Course of Encephalomyelitis

Volker Siffrin, Helena Radbruch, Robert Glumm, +13

Immunity

Vivo ImagingNeurological DisorderMedicineNeurological FunctionImmunology +7

A Vicious Cycle Involving Release of Heat Shock Protein 60 from Injured Cells and Activation of Toll-Like Receptor 4 Mediates Neurodegeneration in the CNS

Seija Lehnardt, Eckart Schott, Thorsten Trimbuch, +5

Journal of Neuroscience

Injured CellsSimilar Inflammatory ResponseImmunologyCell DeathCns Injury +16

Toll-like receptor 2 mediates CNS injury in focal cerebral ischemia

Seija Lehnardt, Sabrina Lehmann, David Kaul, +7

Journal of Neuroimmunology

InflammationMedicineImmunologyCell DeathBrain-immune Interaction +11

Glioma-derived versican promotes tumor expansion via glioma-associated microglial/macrophages Toll-like receptor 2 signaling

Feng Hu, Omar Dzaye, Alexander Hahn, +12

Neuro-Oncology

A Mechanism for Neurodegeneration Induced by Group B Streptococci through Activation of the TLR2/MyD88 Pathway in Microglia

Seija Lehnardt, Philipp Henneke, Egil Lien, +7

The Journal of Immunology

Toll-like receptor 2 mediates microglia/brain macrophage MT1-MMP expression and glioma expansion

Katyayni Vinnakota, Fengyuan Hu, Min‐Chi Ku, +12

Neuro-Oncology