Concepedia

Mechanochemistry for “no solvent, no base” preparation of hydantoin-based active pharmaceutical ingredients: nitrofurantoin and dantrolene

Evelina Colacino, Andrea Porcheddu, Iván Halász, Clarence Charnay, Francesco Delogu, R Sbarbati Del Guerra, Julien Fullenwarth

Green Chemistry · 2018 · 105 citations · 25 references

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Abstract

The gram-scale mechanochemical preparation of marketed drugs Nitrofurantoin and Dantrolene is herein reported.

References

25

The Atom Economy—A Search for Synthetic Efficiency

BM Trost · Science · 1991 · 4.7K citations

, , +14

Using the Right Green Yardstick: Why Process Mass Intensity Is Used in the Pharmaceutical Industry To Drive More Sustainable Processes

Concepción Jiménez‐González, Celia S. Ponder, Quirinus B. Broxterman et al. · Organic Process Research & Development · 2011 · 829 citations

Advances in organometallic synthesis with mechanochemical methods

Nicholas R. Rightmire, Timothy P. Hanusa · Dalton Transactions · 2016 · 361 citations

Organic synthesis by Twin Screw Extrusion (TSE): continuous, scalable and solvent-free

Deborah E. Crawford, Clodagh K. G. Miskimmin, Ahmad B. Albadarin et al. · Green Chemistry · 2017 · 237 citations · Full text

, , +16

Ascorbic Acid as an Initiator for the Direct CH Arylation of (Hetero)arenes with Anilines Nitrosated In Situ

Fernando R. Pinacho Crisóstomo, Tomás Martı́n, Romen Carrillo · Angewandte Chemie International Edition · 2014 · 155 citations