Organic Chemistry Frontiers · 2018 · 55 citations · 65 references
Natural SciencesChemistryMedicinal ChemistryCatalysisOrganic ChemistrySynthetic Medicinal ChemistryHeterocycle SynthesisHeterocyclic ChemistryHeterocyclic CompoundsOrganic SynthesisRetrosynthetic AnalysisAsymmetric Heterocycle SynthesisHeterocycle FunctionalizationIndole ChemistryIndole DerivativesIndole SynthesisSpirocyclic Scaffold DiversificationSpirocyclic ScaffoldsSpiroheterocycle Synthesis
A Zn(OTf)<sub>2</sub> catalyzed Ugi-type reaction of 3-(2-isocyanoethyl)indoles and indole-derived ketimines was developed for the synthesis of hexacyclic spiroindolines featuring three stereocenters including two quaternary stereocenters.
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Collective synthesis of natural products by means of organocascade catalysis
Spencer B. Jones, Bryon Simmons, Anthony Mastracchio et al. · Nature · 2011 · 731 citations
Structural basis for the regulation of tubulin by vinblastine
Benoı̂t Gigant, Chunguang Wang, Raimond B. G. Ravelli et al. · Nature · 2005 · 730 citations