JAAD Case Reports · 2018 · 12 citations · 5 references
PharmacyDermatologyImmunologyMicrofabricationTissue EngineeringTransdermal Drug DeliveryMelasma ManagementMicroneedle-based DeliverySkin Tissue EngineeringTopical PreparationsElastin BiologyMicroneedle Delivery SystemsMicroneedle FabricationMicroneedlesMicroneedling For MelasmaTransdermal Delivery SystemsTransdermal Drug Delivery Systems
Microneedling was first described in the medical literature in 1995 to treat scars and rhytides1 by induction of collagen and elastin synthesis through microtrauma.2 In addition, individual microneedles have been attached to rollers to increase efficiency of puncturing the skin, such as for transdermal drug delivery to treat melasma.3-5 Depth of penetration has been described as ranging from 0.5 to 1.5 mm, which is sufficient to penetrate the papillary dermis.6
5
Microneedling with dermaroller
Satish A Doddaballapur · Journal of Cutaneous and Aesthetic Surgery · 2009 · 217 citations · Full text