Up-regulation of HO-1 promotes resistance of B-cell acute lymphocytic leukemia cells to HDAC4/5 inhibitor LMK-235 via the Smad7 pathway

Apoptosis in podocytes induced by TGF-β and Smad7

Mario Schiffer, Markus Bitzer, Ian S. Roberts et al. · Journal of Clinical Investigation · 2001 · 585 citations · Full text

Medicine, Cell Biology, Nephrology +17

HDAC5 and HDAC9 in Medulloblastoma: Novel Markers for Risk Stratification and Role in Tumor Cell Growth

Till Milde, Ina Oehme, Andrey Korshunov et al. · Clinical Cancer Research · 2010 · 193 citations

Medicine, Molecular Biology, Oncology +13

The Balance between Acetylation and Deacetylation Controls Smad7 Stability

Maria Simonsson, Carl‐Henrik Heldin, Johan Ericsson et al. · Journal of Biological Chemistry · 2005 · 183 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Histone Deacetylase (HDAC) Inhibitors with a Novel Connecting Unit Linker Region Reveal a Selectivity Profile for HDAC4 and HDAC5 with Improved Activity against Chemoresistant Cancer Cells

Linda Marek, Alexandra Hamacher, Finn K. Hansen et al. · Journal of Medicinal Chemistry · 2012 · 182 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +11

MicroRNA-182 targets SMAD7 to potentiate TGFβ-induced epithelial-mesenchymal transition and metastasis of cancer cells

Jingyi Yu, Lei Rong, Xueqian Zhuang et al. · Nature Communications · 2016 · 126 citations · Full text

Medicine, Cancer Biology, Oncology +17