Rational design of mitochondria-targeted pyruvate dehydrogenase kinase 1 inhibitors with improved selectivity and antiproliferative activity

Tyrosine Phosphorylation of Mitochondrial Pyruvate Dehydrogenase Kinase 1 Is Important for Cancer Metabolism

Taro Hitosugi, Jun Fan, Tae‐Wook Chung et al. · Molecular Cell · 2011 · 344 citations · Full text

Life Sciences, Biochemistry, Oncology +17

Regulation of the pyruvate dehydrogenase complex

Mulchand S. Patel, Lioubov G. Korotchkina · Biochemical Society Transactions · 2006 · 289 citations

Life Sciences, Biochemistry, Molecular Biology +13

Pyruvate Dehydrogenase and Pyruvate Dehydrogenase Kinase Expression in Non Small Cell Lung Cancer and Tumor-Associated Stroma

Michael I. Koukourakis, Alexandra Giatromanolaki, Efthimios Sivridis et al. · Neoplasia · 2005 · 216 citations · Full text

Life Sciences, Cell Biology, Oncology +17

Glucose Oxidation Modulates Anoikis and Tumor Metastasis

Sushama Kamarajugadda, Lauren Stemboroski, Qingsong Cai et al. · Molecular and Cellular Biology · 2012 · 216 citations · Full text

Medicine, Cancer Biology, Oncology +17

PDK-1 regulates lactate production in hypoxia and is associated with poor prognosis in head and neck squamous cancer

Simon Wigfield, Stuart C. Winter, Alexandra Giatromanolaki et al. · British Journal of Cancer · 2008 · 188 citations · Full text

Medicine, Cell Biology, Oncology +17