Concepedia

A Practical and Chemoselective Ammonia-Free Birch Reduction

Peng Lei, Yuxuan Ding, Xiaohe Zhang, Adila Adijiang, Hengzhao Li, Yun Ling, Jie An

Organic Letters · 2018 · 116 citations · 32 references

DOI

Concepts

Abstract

A novel protocol for a significantly improved, practical, and chemoselective ammonia-free Birch reduction mediated by bench-stable sodium dispersions and recoverable 15-crown-5 ether is reported. A broad range of aromatic and heteroaromatic compounds is reduced with excellent yields.

References

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