Alkoxylation Followed by Iodination of Oxindole with Alcohols Mediated by Hypervalent Iodine Reagent in the Presence of Iodine

Abstract

Oxidative coupling of oxindole with alcohols followed by in situ iodination by using a PhI(OCOCF 3 ) 2 /I 2 system afforded 5‐iodo‐3‐monoalkoxy and 5‐iodo‐3,3‐di alkoxyoxindole in moderate to good yields. This method provides a new and transition metal‐free synthesis of iodoalkoxy‐substituted oxindoles in one pot from readily available oxindole under mild conditions.