Palladium‐Catalyzed Asymmetric Iodination of Unactivated CH Bonds under Mild Conditions

Abstract

Specific, asymmetric, and mild: Oxazoline (Oxa), a removable chelating chiral auxiliary, assists in the asymmetric activation of C(sp3)H bonds at the β position and C(sp2)H bonds at the γ position. Pd(OAc)2 is an effective catalyst for the selective and asymmetric iodination of methyl, cyclopropyl, and aryl groups at room temperature (see formulae). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2005/z462884_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.