Nature Communications · 2018 · 569 citations · 64 references
Life SciencesImmunologyNephrologyAutoimmunityImmunopathologyInflammationAutoimmune DiseasesB Cell ActivationB Cell BiologyB-cell ResponsesRenal ImmunopathologySystemic Lupus ErythematosusAutoreactive B Cell ResponsesB Cell - Mediated AutoimmunityB-cell Mediated Renal AutoimmunityGlomerular AutoimmunityMurine ModelsPlasma Cell BiologyPlasma Cell DifferentiationSystemic Lupus Erythematosus Associations
Abstract Although the aetiology of systemic lupus erythematosus (SLE) is unclear, dysregulated B cell responses have been implicated. Here we show that an unusual CD11c hi T-bet + B cell subset, with a unique expression profile including chemokine receptors consistent with migration to target tissues, is expanded in SLE patients, present in nephrotic kidney, enriched for autoreactive specificities and correlates with defined clinical manifestations. IL-21 can potently induce CD11c hi T-bet + B cells and promote the differentiation of these cells into Ig-secreting autoreactive plasma cells. While murine studies have identified a role for T-bet-expressing B cells in autoimmunity, this study describes and exemplifies the importance of CD11c hi T-bet + B cells in human SLE.
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HTSeq—a Python framework to work with high-throughput sequencing data
Simon Anders, Paul Theodor Pyl, Wolfgang Huber · Bioinformatics · 2014 · 22.7K citations · Full text