Concepedia

Activation of the vitamin D receptor transcription factor stimulates the growth of definitive erythroid progenitors

Jeffrey Barminko, Brad M. Reinholt, Alexander Emmanuelli, Alannah Lejeune, Margaret H. Baron

Blood Advances · 2018 · 12 citations · 43 references

DOIFull text

Open access

Concepts

Abstract

has a cell-intrinsic function in early erythroid progenitors. Targeting of downstream components of the Vdr signaling pathway may lead to new approaches for the expansion of erythroid progenitors ex vivo.

References

43

Targeted ablation of the vitamin D receptor: An animal model of vitamin D-dependent rickets type II with alopecia

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Development of hematopoietic stem cell activity in the mouse embryo

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Ineffective erythropoiesis in Stat5a−/−5b−/− mice due to decreased survival of early erythroblasts

Merav Socolovsky, Hyung-song Nam, Mark D. Fleming et al. · Blood · 2001 · 679 citations

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Resolving the distinct stages in erythroid differentiation based on dynamic changes in membrane protein expression during erythropoiesis

Ke Chen, Jing Liu, Susanne Heck et al. · Proceedings of the National Academy of Sciences · 2009 · 524 citations · Full text

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Distinct Sources of Hematopoietic Progenitors Emerge before HSCs and Provide Functional Blood Cells in the Mammalian Embryo

Kathleen E. McGrath, Jenna M. Frame, Katherine H. Fegan et al. · Cell Reports · 2015 · 424 citations · Full text

, , +17