Advanced Molecular Targeted Therapy in Breast Cancer

Abstract

Breast cancer is conventionally considered as a heterogeneous disease. Each year more than one million women are diagnosed with breast cancer worldwide over half of whom will die from the disease. Genetics, inheritance, aging are major risk factor for breast cancer, while hormonal factors, obesity and alcohol use presenting more insecure risk. Recently, the rates of metastasis and mortality in breast cancer patients have declined as a result of extensive screening programs and development of new treatments by mammographic screening, chemotherapy, surgery, radiation therapy and adjuvant therapy but suffer the toxic side effects and affect the patient's quality of life. The targeted therapy is the novel technique that brings to halt specific proteins, when certain proteins are blocked or stop working the cancer cells can't grow and they will die. In the present review, we sum up the variety of targets for the management of breast cancer, and targeted drug therapy for it.