Concepedia

Targeted Covalent Inhibition of Prolyl Oligopeptidase (POP): Discovery of Sulfonylfluoride Peptidomimetics

Salvador Guardiola, Roger Prades, Laura Mendieta, Arwin J. Brouwer, Jelle Streefkerk, Laura Nevola, Teresa Tarragó, Rob M. J. Liskamp, Ernest Giralt

Cell chemical biology · 2018 · 49 citations · 31 references

DOIFull text

Open access

Concepts

References

31

On the size of the active site in proteases. I. Papain

Israël Schechter, Arieh Berger · Biochemical and Biophysical Research Communications · 1967 · 5.2K citations

, , +9

High throughput artificial membrane permeability assay for blood–brain barrier

Li Di, Edward H. Kerns, Kristi Fan et al. · European Journal of Medicinal Chemistry · 2003 · 1.1K citations

, , +11

Sulfonyl fluorides as privileged warheads in chemical biology

Arjun Narayanan, Lyn H. Jones · Chemical Science · 2015 · 543 citations · Full text

, , +5

Prolyl Oligopeptidase

Vilmos Fülöp, Zsolt Böcskei, László Polgár · Cell · 1998 · 494 citations · Full text

Evaluation of the MDR-MDCK cell line as a permeability screen for the blood–brain barrier

Qing Wang, Joseph Rager, Kathryn E. Weinstein et al. · International Journal of Pharmaceutics · 2004 · 345 citations

, , +9