Concepedia

Clinical Application of Circulating Tumor Cells and Circulating Tumor DNA in Uveal Melanoma

Aaron B. Beasley, Timothy Isaacs, Muhammad A. Khattak, James Freeman, Richard Allcock, Fred K. Chen, Michelle R. Pereira, Kyle S. Yau, Jaqueline Bentel, Tersia Vermeulen,

JCO Precision Oncology · 2018 · 56 citations · 29 references

DOIFull text

Open access

Abstract

The presence of CTCs in localized UM can be used to ascertain prognostic SCNA, whereas ctDNA can be used to monitor patients for early signs of metastatic disease. This study paves the way for the analysis of CTCs and ctDNA as a liquid biopsy that will assist with treatment decisions in patients with UM.

References

29

Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies

Chetan Bettegowda, Mark Sausen, Rebecca Leary et al. · Science Translational Medicine · 2014 · 5K citations · Full text

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Detection of Mutations in <i>EGFR</i> in Circulating Lung-Cancer Cells

Shyamala Maheswaran, Lecia V. Sequist, Sunitha Nagrath et al. · New England Journal of Medicine · 2008 · 1.6K citations · Full text

Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi

Catherine D. Van Raamsdonk, Vladimir Bezrookove, Gary Green et al. · Nature · 2008 · 1.6K citations · Full text

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Very Long-Term Prognosis of Patients with Malignant Uveal Melanoma

Emma Kujala, Teemu Ma ̈kitie, Tero Kivelä · Investigative Ophthalmology & Visual Science · 2003 · 1K citations

Integrative Analysis Identifies Four Molecular and Clinical Subsets in Uveal Melanoma

A. Gordon Robertson, Juliann Shih, Christina Yau et al. · Cancer Cell · 2017 · 888 citations · Full text

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