Concepedia

Estrogen receptor positive breast tumors resist chemotherapy by the overexpression of P53 in Cancer Stem Cells

Fatma Ashour, Mohammed H. Awwad, Hayam E.L. Sharawy, Mohamed Kamal

Journal of the Egyptian National Cancer Institute · 2018 · 16 citations · 18 references

DOIFull text

Open access

Abstract

Our results suggest that CSCs in the ER<sup>+</sup> cells escape the effect of DOX treatment by the elevation of p53 expression.

References

18

Prospective identification of tumorigenic breast cancer cells

Muhammad Al‐Hajj, Max S. Wicha, Adalberto Benito‐Hernández et al. · Proceedings of the National Academy of Sciences · 2003 · 10.3K citations · Full text

Participation of p53 protein in the cellular response to DNA damage.

Michael B. Kastan, Onyinye Onyekwere, D Sidransky et al. · PubMed · 1991 · 3.8K citations

, , +17

An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death

Amer A. Beg, David Baltimore · Science · 1996 · 3.1K citations

Estrogen-Receptor Status and Outcomes of Modern Chemotherapy for Patients With Node-Positive Breast Cancer

Donald A. Berry, Constance Cirrincione, I. Craig Henderson et al. · JAMA · 2006 · 730 citations · Full text

Stem cells in normal breast development and breast cancer

MS Wicha, Gabriela Dontu, Muhammad Al‐Hajj et al. · Breast Cancer Research · 2003 · 540 citations · Full text