Concepedia

Discovery of novel small molecule TLR4 inhibitors as potent anti-inflammatory agents

Yao Xu, Shujun Chen, Ying Cao, Pingzheng Zhou, Zhipeng Chen, Kui Cheng

European Journal of Medicinal Chemistry · 2018 · 51 citations · 20 references

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References

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The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

Beom Seok Park, Dong Hyun Song, Ho Min Kim et al. · Nature · 2009 · 2.4K citations

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Reconstruction of LPS Transfer Cascade Reveals Structural Determinants within LBP, CD14, and TLR4-MD2 for Efficient LPS Recognition and Transfer

Je‐Kyung Ryu, Soo Jin Kim, Sang-Hyun Rah et al. · Immunity · 2016 · 434 citations · Full text

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Carvedilol and its new analogs suppress arrhythmogenic store overload–induced Ca2+ release

Qiang Zhou, Jianmin Xiao, Dawei Jiang et al. · Nature Medicine · 2011 · 251 citations

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Inhibitory effect of naringin on lipopolysaccharide (LPS)-induced endotoxin shock in mice and nitric oxide production in RAW 264.7 macrophages

Syu‐ichi Kanno, Ai Shouji, Ayako Tomizawa et al. · Life Sciences · 2005 · 162 citations

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Up‐regulated <scp>TLR</scp>4 in cardiomyocytes exacerbates heart failure after long‐term myocardial infarction

Li Liu, Wang Yin, Zhiyong Cao et al. · Journal of Cellular and Molecular Medicine · 2015 · 160 citations · Full text

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