Inhibition of Cyclic <scp>GMP</scp> ‐ <scp>AMP</scp> Synthase Using a Novel Antimalarial Drug Derivative in <i>Trex1</i> ‐Deficient Mice

Abstract

This study demonstrates that X6 is superior to HCQ for the treatment of an experimental autoimmune myocarditis mediated in vivo by the cGAS/stimulator of IFN genes (cGAS/STING) pathway. The findings suggest that drug X6 could be developed as a novel treatment for AGS and/or lupus to inhibit activation of the cGAS/STING pathway.