Movement Disorders · 2018 · 37 citations · 9 references
Life SciencesNeurobiologyNeuroscienceBehavioral NeuroscienceNeuropharmacologyPain ScienceNociceptive PainPain MechanismsPain NeurobiologyPain NeurosciencePain ProcessingSpinal Cord PhysiologyDorsal Horn HyperexcitabilityDorsal Horn NeurophysiologyNociceptive TransmissionNociceptor HyperexcitabilityPain HypersensitivitySpinal Cord IntegrationSpinal Cord Pain ProcessingSpinal Excitability
BACKGROUND: Pain is a major non motor symptom that contributes to impaired quality of life in PD. However, its mechanism is unknown. OBJECTIVES AND METHODS: We sought to identify the pain phenotypes and parallel changes in spinal integration of peripheral stimuli in a rat model of PD induced by lesions of SN dopamine neurons, using behavioral plantar and von Frey tests as well as electrophysiology of the dorsal horn. RESULTS: We show that dopamine depletion by 6-OHDA induced hypersensitivity to mechanical and thermal stimuli. These abnormal behaviors were paralleled by increased neuronal responses and hyperexcitability of wide dynamic range neurons of lamina V of the dorsal horn of the spinal cord in response to electrical stimulation of the sciatic nerve in the 6-OHDA model as compared to sham rats. CONCLUSIONS: These results provide evidence for alteration of nociceptive integration in the spinal dorsal horn neurons in 6-OHDA rats that can reflect changes in pain behavior. © 2018 International Parkinson and Movement Disorder Society.
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