Concepedia

Hypertrophic cardiomyopathy mutations increase myofilament Ca2+ buffering, alter intracellular Ca2+ handling, and stimulate Ca2+-dependent signaling

Paul Robinson, Xing Liu, Alexander J. Sparrow, Suketu Patel, Yin Hua Zhang, Barbara Casadei, Hugh Watkins, Charles Redwood

Journal of Biological Chemistry · 2018 · 91 citations · 43 references

DOIFull text

Open access

Concepts

Abstract

sensitivity provides an attractive therapeutic approach in HCM.

References

43

A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes.

C H Luo, Yoram Rudy · Circulation Research · 1994 · 1.6K citations

, , +17

An Expanded Palette of Genetically Encoded Ca <sup>2+</sup> Indicators

Yongxin Zhao, Satoko Araki, Jiahui Wu et al. · Science · 2011 · 1.3K citations · Full text

, , +17

α-tropomyosin and cardiac troponin T mutations cause familial hypertrophic cardiomyopathy: A disease of the sarcomere

Ludwig Thierfelder, Hugh Watkins, Calum A. MacRae et al. · Cell · 1994 · 1K citations

, , +10

Sudden death in young athletes.

Barry J. Maron, William C. Roberts, Hugh A. McAllister et al. · Circulation · 1980 · 836 citations

, , +13

Prognostic Significance of Myocardial Fibrosis in Hypertrophic Cardiomyopathy

Rory O’Hanlon, Agata Grasso, James Moon et al. · Journal of the American College of Cardiology · 2010 · 814 citations

, , +11