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Evaluation of a Commercial Immuno-Chromatographic Assay Kit for Rapid Detection of IgM Antibodies against <i>Leptospira</i> Antigen in Human Serum

Fairuz Amran, Yii Ling Liow, Nurul Atiqah Noor Halim

Journal of Korean Medical Science · 2018 · 10 citations · 9 references

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Abstract

Leptospirosis is a febrile zoonotic disease. Routine diagnosis of leptospirosis is based on the detection of specific antibodies with serological tests. The aim of our study was to determine the usefulness of immunochromatographic assay (ICA), ImmuneMed Leptospira IgM Duo Rapid test kit from Korea, in rapid screening of acute leptospirosis in emergency cases with limited expertise. A total of 197 serum samples (93 positive, 104 negative) were selected randomly. The test has good diagnostic sensitivity 73% and specificity 90%. With positive predictive value of 87% and negative predictive value of 79%, this reassures patients have higher chance of correct diagnosis. This ICA is acceptable for screening of leptospirosis but confirmation with microscopic agglutination test should follow.

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Marga G. A. Goris, Mariska Leeflang · Journal of Bacteriology & Parasitology · 2012 · 42 citations · Full text

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