Radical‐Induced, Palladium‐Catalyzed C–H Activation: An Approach to Functionalize 4<i>H</i>‐Benzo[<i>d</i>][1,3]oxazin‐4‐one Derivatives by Using Toluenes, Aldehydes, and Benzyl Alcohols

Abstract

Toluenes, aldehydes, and benzyl alcohols have been utilized in the radical‐induced direct functionalization of 4 H ‐benzo[ d ][1,3]oxazin‐4‐one derivatives by using a palladium‐catalyzed C–H activation strategy. The stability, low toxicity, and ease of access to toluenes, aldehydes, and benzyl alcohols have made them suitable candidates for this transformation. The reaction proceeded smoothly with high functional group compatibility and afforded the desired products in moderate to good yields. Mechanistic investigations illustrate the radical pathway and highlight the importance of both catalyst and oxidant.