ACS Chemical Biology · 2018 · 30 citations · 37 references
Life SciencesMicrobiologyPharmacologyMicrobial MetabolismMicrobial PhysiologyMicrobiome ResearchGastrointestinal PharmacologyGut MicrobiomeGut MicrobiotaMicrobial FermentationMicrobial Metabolite ProductionMicrobiome TherapeuticsAntibiotic Effects On The Gut MicrobiomeBacteroides SpeciesChemical Probe SelectivityGut Microbiota EffectsIntestinal Microbiota ModulationMicrobial Ecology Of The GutStarch ConversionStarch Utilization
A new approach for the nonmicrobicidal phenotypic manipulation of prominent gastrointestinal microbes is presented. Low micromolar concentrations of a chemical probe, acarbose, can selectively inhibit the Starch Utilization System and ablate the ability of Bacteroides thetaiotaomicron and B. fragilis strains to metabolize potato starch and pullulan. This strategy has potential therapeutic relevance for the selective modulation of the GI microbiota in a nonmicrobicidal manner.
37
An obesity-associated gut microbiome with increased capacity for energy harvest
Peter J. Turnbaugh, Ruth E. Ley, Michael A. Mahowald et al. · Nature · 2006 · 12.4K citations
A core gut microbiome in obese and lean twins
Peter J. Turnbaugh, Micah Hamady, Tanya Yatsunenko et al. · Nature · 2008 · 7.9K citations · Full text
A metagenome-wide association study of gut microbiota in type 2 diabetes
Junjie Qin, Yingrui Li, Zhiming Cai et al. · Nature · 2012 · 7K citations · Full text