Identification of <i>Lycopodium</i> Alkaloids Produced by an Ultraviolet-Irradiated Strain of <i>Paraboeremia</i>, an Endophytic Fungus from <i>Lycopodium serratum</i> var. <i>longipetiolatum</i>

Abstract

12- epi-Lycopodine (1), a Lycopodium alkaloid, along with lycopodine (2) and huperzine A (3), were discovered in the mycelium of Paraboeremia sp. Lsl3KI076, a UV-irradiated strain of Paraboeremia sp. Lsl3, an endophytic fungus from Lycopodium serratum Thunb. var. longipetiolatum Spring. Additionally, a trace of 1 was isolated from Phlegmariurus nummulariifolius (Blume) Ching, and the structure was elucidated on the basis of spectroscopic data. This is the first report proving that a new naturally occurring Lycopodium alkaloid can be obtained from an endophytic fungus.