Laser Physics · 2018 · 25 citations · 16 references
EngineeringBioengineeringBiomedical EngineeringBiophotonicsBiosensorsPhotonicsBiomedical SensorsOptical BiosensingOptical BiosensorsOptical SensingOptical SensorsPhotonic CrystalsBiosensor Sensitivity EnhancementLabel-free BiosensingLabel-free Optical BiosensingOptical Band GapPhotonic Crystal BiosensorsPhotonic Crystal WaveguidesRefractive Index BiosensingTwo-dimensional Photonic Crystals
Abstract In this paper, a two-dimensional photonic crystal biosensor for medical applications based on two waveguides and a nanocavity was explored with different shoulder-coupled nanocavity structures. The most important biosensor parameters, like the sensitivity and quality factor, can be significantly improved. By injecting an analyte into a sensing hole, the refractive index of the hole was changed. This refractive index biosensor senses the changes and shifts its operating wavelength accordingly. The transmission characteristics of light in the biosensor under different refractive indices that correspond to the change in the analyte concentration are analyzed by the finite-difference time-domain method. The band gap for each structure is designed and observed by the plane wave expansion method. These proposed structures are designed to obtain an analyte refractive index variation of about 1–1.5 in an optical wavelength range of 1.250–1.640 µ m. Accordingly, an improved sensitivity of 136.6 nm RIU −1 and a quality factor as high as 3915 is achieved. An important feature of this structure is its very small dimensions. Such a combination of attributes makes the designed structure a promising element for label-free biosensing applications.
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Compendium of chemical terminology
Victor Gold · 1987 · 2.5K citations
Cell refractive index tomography by digital holographic microscopy
Florian Charrière, Anca Marian, Frédéric Montfort et al. · Optics Letters · 2006 · 563 citations · Full text
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Nina Skivesen, Amélie Têtu, Martin Kristensen et al. · Optics Express · 2007 · 324 citations · Full text