Concepedia

Targeting protein biotinylation enhances tuberculosis chemotherapy

Divya Tiwari, Sae Woong Park, Maram M. Essawy, Surendra Dawadi, Alan Mason, Madhumitha Nandakumar, Matthew Zimmerman, Marizel Mina, Hsin Pin Ho, Curtis A. Engelhart,

Science Translational Medicine · 2018 · 33 citations · 30 references

DOIFull text

Open access

Concepts

Abstract

Inhibitors of biotin protein ligase and protein biotinylation in Mycobacterium tuberculosis act synergistically with the drug rifampicin, potentially shortening tuberculosis treatment.

References

30

Chemotherapy and management of tuberculosis in the United Kingdom: recommendations 1998

T Joint · Thorax · 1998 · 533 citations · Full text

, , +17

A replication clock for Mycobacterium tuberculosis

Wendy Gill, Nada Harik, Molly R Whiddon et al. · Nature Medicine · 2009 · 338 citations · Full text

, , +14

Ancestral antibiotic resistance in <i>Mycobacterium tuberculosis</i>

Rowan P. Morris, Liem Nguyen, John Gatfield et al. · Proceedings of the National Academy of Sciences · 2005 · 329 citations

, , +17

Role of individual drugs in the chemotherapy of tuberculosis.

D.A. Mitchison · PubMed · 2000 · 314 citations

, , +11

A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy

Kévin Pethe, Patrícia Carvalho de Sequeira, Sanjay Agarwalla et al. · Nature Communications · 2010 · 308 citations · Full text

, , +12