PEP06 polypeptide 30 exerts antitumour effect in colorectal carcinoma <i>via</i> inhibiting epithelial–mesenchymal transition

Siming Yu, Linna Li, Wei Tian, Dan Nie, Wei Mu, Fang Qiu, Yu Liu, Xinghan Liu, Xiaofeng Wang, Zhimin Du,

British Journal of Pharmacology · 2018 · 22 citations · 41 references

DOIFull text

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Abstract

PEP06 is a polypeptide that inhibits the growth and metastasis of colon cancer through its RGD motif binding to integrin αvβ3, thereby down-regulating miR-146b-5p to inhibit EMT in vitro and in vivo. It might have potential as a therapeutic for CRC.

References

41