PRN473, an inhibitor of Bruton's tyrosine kinase, inhibits neutrophil recruitment <i>via</i> inhibition of macrophage antigen‐1 signalling

Abstract

PRN473, a highly selective inhibitor of Btk, potently attenuates sterile liver injury by inhibiting the activation of the β₂ -integrin Mac-1 and subsequently neutrophil recruitment into inflamed tissue.