Concepedia

The cycloaspeptides: uncovering a new model for methylated nonribosomal peptide biosynthesis

Kate M. J. de Mattos-Shipley, Claudio Greco, David M. Heard, Gemma Hough, Nicholas P. Mulholland, Jason Micklefield, Thomas J. Simpson, Christine L. Willis, Russell J. Cox, Andy M. Bailey

Chemical Science · 2018 · 37 citations · 20 references

DOIFull text

Open access

Concepts

Abstract

The cycloaspeptide gene cluster includes a pathway-specific <italic>N</italic>-methyl transferase. Its disruption allowed incorporation of <italic>N</italic>-methylated amino acids provided in the culture medium, allowing efficient production of cycloaspeptide E and novel related products.

References

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Marnix H. Medema, Kai Blin, Peter Cimermančič et al. · Nucleic Acids Research · 2011 · 2K citations · Full text

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Estimating the Economic Cost of One of the World's Major Insect Pests, &lt;I&gt;Plutella xylostella&lt;/I&gt; (Lepidoptera: Plutellidae): Just How Long Is a Piece of String?

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Structures of two distinct conformations of holo-non-ribosomal peptide synthetases

Eric J. Drake, Bradley R. Miller, Ce Shi et al. · Nature · 2016 · 249 citations · Full text

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