Elevated expression of keratin 17 in oropharyngeal squamous cell carcinoma is associated with decreased survival

Abstract

Abstract Background Overexpression of keratin 17 (K17) is highly associated with poor prognosis in squamous cell carcinoma (SCC) of the cervix. This study was performed to (1) determine whether K17 may be a prognostic biomarker in head and neck squamous cell carcinoma (HNSCC) and (2) to establish if K17 expression is associated with human papillomavirus (HPV) status. Methods Immunohistochemical staining was performed for K17 of oral, oropharyngeal, and laryngeal SCCs, and normal oropharyngeal mucosa. The HPV status was determined using polymerase chain reaction (PCR). Results Elevated K17 expression was significantly associated with an overall decreased patient survival ( P = .02) and, more specifically, in patients with oropharyngeal SCC ( P = .01). When controlling for HPV status and tumor location K17 was still a significant predictor of survival ( P = .01). Conclusion Therefore, K17 is a novel prognostic biomarker of poor survival for patients with HNSCCs, controlling for anatomic site and HPV status.