Nature Communications · 2018 · 102 citations · 41 references
MedicineImmunologyOncologyCancer ImmunologyMolecular OncologyTumor MicroenvironmentImmune Checkpoint ModulationImmune Checkpoint RegulationMicrorna-mediated RegulationOncogenic VirusesT Cell ExhaustionViral HepatitisChronic Hepatitis B - Associated CarcinomaHost Factors In InfectionMicrorna Function In CancerMicrorna In CancerMicrorna Regulation In CancerPd-l1 BlockadeStat3 SignalingTumor Microenvironment Effects
Abstract A chronic viral or tumor microenvironment can push T cells to exhaustion by promoting coinhibitory ligand expression. However, how host factors control coinhibitory ligand expression and whether viral infection breaks this control during tumor progress is unknown. Here we show a close negative correlation between SALL4 or PD-L1 and miR-200c in tumors from 98 patients with HBV-related hepatocellular carcinoma. SALL4 or PD-L1 expression correlates negatively with miR-200c expression, and patients with lower levels of SALL4 or PD-L1 and higher miR-200c survive longer. Moreover, over-expression of miR-200c antagonizes HBV-mediated PD-L1 expression by targeting 3ʹ-UTR of CD274 (encoding PD-L1) directly, and reverses antiviral CD8 + T cell exhaustion. MiR-200c transcription is inhibited by oncofetal protein SALL4, which is re-expressed through HBV-induced STAT3 activation in adulthood. We propose that an HBV-pSTAT3-SALL4-miR-200c axis regulates PD-L1. Therapeutic strategies to influence this axis might reverse virus-induced immune exhaustion.
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Aberrant PD-L1 expression through 3′-UTR disruption in multiple cancers
Keisuke Kataoka, Yuichi Shiraishi, Yohei Takeda et al. · Nature · 2016 · 638 citations