Concepedia

Publication | Open Access

Protective Effects of Topiroxostat on an Ischemia-Reperfusion Model of Rat Hearts

DOIFull Paper Access

16

Citations

27

References

2018

Year

Shogo Tanno, Kenshiro Yamamoto, Yasutaka Kurata, Maya Adachi, Yumiko Inoue, Naoyuki Otani, Mutsuo Mishima, Yasutaka Yamamoto, Masanari Kuwabara, Kazuhíde Oginö,
Circulation Journal

Abstract

Topiroxostat showed protective effects against I/R injury with higher potency than allopurinol or NAC. It dramatically inhibited XO activity and TBARS production, suggesting suppression of ROS generation.

References

YearCitations

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