Base‐Promoted Carbonylative Cyclization of Propargylic Amines with Selenium under CO Gas‐free Conditions

Abstract

Abstract We report here a new carbonylative procedure for the cyclization of propargylic amines with elemental selenium (Se). By using t BuOK as the promoter, various 1,3‐selenazolidin‐2‐ones were produced without the usage of toxic CO gas. Benzene‐1,3,5‐triyl triformate (TFBen) was employed as a safe and convenient CO surrogate here, and a broad class of substrates (29 examples) were effectively transformed into the desired products in 50–97% yields under mild conditions. magnified image