Publication | Open Access
Linking PRMT5 to breast cancer stem cells: New therapeutic opportunities?
11
Citations
9
References
2018
Year
Breast OncologyEpigenetic ChangeArginine Methyltransferase Prmt5EpigeneticsTumor BiologyStem CellsRadiation OncologyCancer ResearchTumour RelapseHealth SciencesPrmt5 InhibitorsGene ExpressionEpigenetic RegulationCell BiologyNew Therapeutic OpportunitiesChromatinLineage PlasticityInduced Pluripotent Stem CellEpigenomicsStem Cell ResearchBreast CancerTumor SuppressorMedicineEmbryonic Stem Cell
The arginine methyltransferase PRMT5 has been increasingly associated with cancer development. Here we describe our recent findings that PRMT5 is a critical regulator of breast cancer stem cell survival via the epigenetic regulation of FOXP1. Consequently, PRMT5 inhibitors could potentially eradicate cancer stem cells thereby preventing tumour relapse.
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