Concepedia

A Novel Tetramethylpyrazine Derivative Prophylactically Protects against Glutamate-Induced Excitotoxicity in Primary Neurons through the Blockage of N-Methyl-D-aspartate Receptor

Shengquan Hu, Huihui Hu, Shinghung Mak, Guozhen Cui, Luchen Shan, Yuqiang Wang, Huangquan Lin, Zaijun Zhang, Yifan Han

Frontiers in Pharmacology · 2018 · 30 citations · 35 references

DOIFull text

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Concepts

Abstract

influx and to the downstream GSK3β cascade.

References

35

Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss

Maria Talantova, Sara Sanz‐Blasco, Xiaofei Zhang et al. · Proceedings of the National Academy of Sciences · 2013 · 589 citations · Full text

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Inhibition of Drp1 Ameliorates Synaptic Depression, Aβ Deposition, and Cognitive Impairment in an Alzheimer's Disease Model

So Jung Park, Jae In Jeong, Sung Hyun Kim et al. · Journal of Neuroscience · 2017 · 260 citations · Full text

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Alzheimer's disease, a multifactorial disorder seeking multitherapies

Khalid Iqbal, Inge Grundke‐Iqbal · Alzheimer s & Dementia · 2010 · 255 citations

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Glutamate-induced apoptosis in neuronal cells is mediated via caspase-dependent and independent mechanisms involving calpain and caspase-3 proteases as well as apoptosis inducing factor (AIF) and this process is inhibited by equine estrogens

Yuemei Zhang, Bhagu R. Bhavnani · BMC Neuroscience · 2006 · 213 citations · Full text

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Encoding and Transducing the Synaptic or Extrasynaptic Origin of NMDA Receptor Signals to the Nucleus

Anna Karpova, Marina Mikhaylova, Sujoy Bera et al. · Cell · 2013 · 195 citations · Full text

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