Glucocorticoids induce apoptosis and matrix metalloproteinase-13 expression in chondrocytes through the NOX4/ROS/p38 MAPK pathway

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

John C. Lee, Jeffrey T. Laydon, Peter McDonnell et al. · Nature · 1994 · 3.3K citations

Inflammation, Cytokine, Signal Transduction +13

The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis response to tumor necrosis factor.

Rudi Beyaert, Ana Cuenda, Wim Vanden Berghe et al. · The EMBO Journal · 1996 · 650 citations · Full text

Inflammation, Cytokine, Apoptosis +10

Glucocorticoids and Tumor Necrosis Factor α Increase Oxidative Stress and Suppress Wnt Protein Signaling in Osteoblasts

Maria Almeida, Han Li, Elena Ambrogini et al. · Journal of Biological Chemistry · 2011 · 272 citations · Full text

Inflammation, Inflammatory Cytokines, Metabolic Bone Disease +15

p38 Mitogen-Activated Protein Kinase (MAPK) Is a Key Mediator in Glucocorticoid-Induced Apoptosis of Lymphoid Cells: Correlation between p38 MAPK Activation and Site-Specific Phosphorylation of the Human Glucocorticoid Receptor at Serine 211

Aaron L. Miller, M. Scott Webb, Alicja J. Copik et al. · Molecular Endocrinology · 2005 · 236 citations · Full text

P38 Mapk Signaling, Apoptosis, Immunology +19

Dexamethasone Induces Apoptosis in Proliferative Chondrocytes through Activation of Caspases and Suppression of the Akt-Phosphatidylinositol 3′-Kinase Signaling Pathway

Dionisios Chrysis, Farasat Zaman, Andrei S. Chagin et al. · Endocrinology · 2004 · 141 citations

Inflammation, Anti-inflammatory, Longitudinal Growth +15