Experimental Demyelination and Axonal Loss Are Reduced in MicroRNA-146a Deficient Mice

Abstract

During demyelination, absence of miR-146a reduced inflammatory responses, demyelination, axonal loss, the number of infiltrating macrophages, and increased the number of myelinating oligodendrocytes. The number of OPCs was slightly higher in the WT mice during remyelination, indicating a complex role of miR-146a during <i>in vivo</i> de- and remyelination.