Evodiamine activates cellular apoptosis through suppressing PI3K/AKT and activating MAPK in glioma - Concepedia

Concepedia

Publication | Open Access

Evodiamine activates cellular apoptosis through suppressing PI3K/AKT and activating MAPK in glioma

DOI Full Paper Access

56

Citations

20

References

2018

Year

Rong Wang, Danni Deng, Yuan Xu, Lian Xue, Ya Peng, Yatian Liu, Feng Zhi

OncoTargets and Therapy

Abstract

In summary, Evo inhibits cell proliferation by inducing cellular apoptosis via suppressing PI3K/AKT and activating MAPK in GBM; these results indicate that Evo may be regarded as a new approach for GBM treatment.

References

	Year	Citations
Reactive Oxygen Species Promote TNFα-Induced Death and Sustained JNK Activation by Inhibiting MAP Kinase Phosphatases Hideaki Kamata, Shinichi Honda, Shin Maeda, Cell InflammationRedox SignalingSignal TransductionApoptosisImmunology	2005	1.8K
Anti-cancer natural products isolated from chinese medicinal herbs Wen Tan, Jin‐Jian Lu, Mingqing Huang, Chinese Medicine	2011	394
Emodin induces apoptosis in human lung adenocarcinoma cells through a reactive oxygen species-dependent mitochondrial signaling pathway Yuting Su, Huei-Ling Chang, Song‐Kun Shyue, Biochemical Pharmacology Mitochondrial FunctionMedicineLipid PeroxidationApoptosisAutophagy	2005	246
The role of MAPK pathways in the action of chemotherapeutic drugs Simone Boldt Carcinogenesis Chemoprevention StrategyApoptosisCell DeathSelective Mapk InhibitorsSignaling Pathway	2002	177
Low-grade gliomas in adults Nader Sanai, Susan M. Chang, Mitchel S. Berger Journal of neurosurgery Pediatric Brain TumorsOncologic ImagingMolecular MarkersHigh-grade GliomasLow-grade Gliomas	2011	150
Low-Grade Gliomas in Adults Jeanine T. Grier, Tracy T. Batchelor The Oncologist	2006	122
Role of mitochondria in ultraviolet-induced oxidative stress Robert Gniadecki, Tine Thorn, Jana Vic̀anová, Journal of Cellular Biochemistry	2000	121
Anti-inflammatory and anti-infectious effects of Evodia rutaecarpa (Wuzhuyu) and its major bioactive components Jyh‐Fei Liao, Wen‐Fei Chiou, Yuh‐Chiang Shen, Chinese Medicine	2011	93
Evodiamine, a plant alkaloid, induces calcium/JNK-mediated autophagy and calcium/mitochondria-mediated apoptosis in human glioblastoma cells Ann-Jeng Liu, Sheng-Hao Wang, Ku‐Chung Chen, Chemico-Biological Interactions Neuro-oncologyMitophagyCell AutophagyPlant AlkaloidMedicine	2013	80
Evodiamine-induced human melanoma A375-S2 cell death was mediated by PI3K/Akt/caspase and Fas-L/NF-κB signaling pathways and augmented by ubiquitin–proteasome inhibition Che Wang, Song Li, Minwei Wang Toxicology in Vitro Cancer ResearchUbiquitin–proteasome InhibitionFas-l/nf-κb Signaling PathwaysCell RegulationMedicine	2009	73

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