Concepedia

Evodiamine activates cellular apoptosis through suppressing PI3K/AKT and activating MAPK in glioma

Rong Wang, Danni Deng, Yuan Xu, Lian Xue, Ya Peng, Yatian Liu, Feng Zhi

OncoTargets and Therapy · 2018 · 56 citations · 20 references

DOIFull text

Open access

Abstract

In summary, Evo inhibits cell proliferation by inducing cellular apoptosis via suppressing PI3K/AKT and activating MAPK in GBM; these results indicate that Evo may be regarded as a new approach for GBM treatment.

References

20

Reactive Oxygen Species Promote TNFα-Induced Death and Sustained JNK Activation by Inhibiting MAP Kinase Phosphatases

Hideaki Kamata, Shinichi Honda, Shin Maeda et al. · Cell · 2005 · 1.8K citations · Full text

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Anti-cancer natural products isolated from chinese medicinal herbs

Wen Tan, Jin‐Jian Lu, Mingqing Huang et al. · Chinese Medicine · 2011 · 394 citations · Full text

Emodin induces apoptosis in human lung adenocarcinoma cells through a reactive oxygen species-dependent mitochondrial signaling pathway

Yuting Su, Huei-Ling Chang, Song‐Kun Shyue et al. · Biochemical Pharmacology · 2005 · 246 citations

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The role of MAPK pathways in the action of chemotherapeutic drugs

Simone Boldt · Carcinogenesis · 2002 · 177 citations · Full text

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Low-grade gliomas in adults

Nader Sanai, Susan M. Chang, Mitchel S. Berger · Journal of neurosurgery · 2011 · 150 citations

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