Role of LRRK2 in manganese-induced neuroinflammation and microglial autophagy

Autophagy Controls IL-1β Secretion by Targeting Pro-IL-1β for Degradation

James Harris, Michelle Hartman, Caitrionna Roche et al. · Journal of Biological Chemistry · 2011 · 785 citations · Full text

Life Sciences, Cell Biology, Immunology +17

Disease‐specific phenotypes in dopamine neurons from human iPS‐based models of genetic and sporadic Parkinson's disease

Adriana Sánchez‐Danés, Yvonne Richaud‐Patín, Iria Carballo‐Carbajal et al. · EMBO Molecular Medicine · 2012 · 565 citations · Full text

Life Sciences, Neurology, Neuroscience +17

LRRK2 Inhibition Attenuates Microglial Inflammatory Responses

Mark S. Moehle, Philip J. Webber, Tonia E. Tse et al. · Journal of Neuroscience · 2012 · 476 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration

Wanli W. Smith, Zhong Pei, Haibing Jiang et al. · Proceedings of the National Academy of Sciences · 2005 · 418 citations · Full text

Life Sciences, Neurology, Neuroscience +17

Parkinson’s disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures

Mansoureh Hakimi, Thirumahal Selvanantham, Erika Swinton et al. · Journal of Neural Transmission · 2011 · 292 citations

Life Sciences, Immunology, Molecular Genetics +15