Concepedia

Site-specific O-glycosylation of members of the low-density lipoprotein receptor superfamily enhances ligand interactions

Shengjun Wang, Yang Mao, Yoshiki Narimatsu, Zilu Ye, Weihua Tian, Christoffer K. Goth, Erandi Lira‐Navarrete, Asier Benito‐Vicente, César Martı́n, Kepa B. Uribe,

Journal of Biological Chemistry · 2018 · 82 citations · 46 references

DOIFull text

Open access

Concepts

Abstract

-glycosylation increased affinity for LDL by ∼5-fold. The molecular basis for this observation is currently unknown, but these findings open up new avenues for exploring the roles of LDLR-related proteins in disease.

References

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