Concepedia

Role of<i>PTPN2/22</i>polymorphisms in pathophysiology of Crohn’s disease

Robert C. Sharp, Shazia Bég, Saleh A. Naser

World Journal of Gastroenterology · 2018 · 21 citations · 12 references

DOIFull text

Open access

Abstract

The data suggests that SNPs in <i>PTPN2/22</i> affect the negative regulation of the immune response in CD patients, thus leading to an increase in inflammation/apoptosis and susceptibility of mycobacteria.

References

12

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PTPN2 Gene Variants Are Associated with Susceptibility to Both Crohn's Disease and Ulcerative Colitis Supporting a Common Genetic Disease Background

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Mycobacterium avium uses apoptotic macrophages as tools for spreading

Julie V. Early, Kay A. Fischer, Luiz E. Bermudez · Microbial Pathogenesis · 2010 · 66 citations · Full text

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