Stem Cell Reports · 2017 · 42 citations · 51 references
DentistryCraniofacial BiologyDevelopmental BiologyBone MetabolismCircadian RhythmsCraniofacial GeneticsCircadian Clock MechanismsCircadian Molecular MechanismsJaw DevelopmentMandibular DevelopmentMandibular GrowthSkeletal DevelopmentCircadian Transcriptional RegulationClock-bmal1 HeterodimerDysplasia ProgressionMandibular Growth DeclineMandibular MorphogenesisPediatric Obstructive Sleep ApneaSleep Apnea Syndrome
mice. Given these findings, we set out to characterize the underlying mechanism and found BMAL1 deficiency enhanced Mmp3 transcription through activating p65 phosphorylation. Together, our results provide insight into the mechanism by which BMAL1 is implicated in the pathogenesis of SMH.
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Obstructive Sleep Apnea as a Risk Factor for Stroke and Death
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Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes
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