Nanoparticle orientation to control RNA loading and ligand display on extracellular vesicles for cancer regression

Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

Hadi Valadi, Karin M. Ekström, Apostolos Bossios et al. · Nature Cell Biology · 2007 · 12.6K citations

Novel Mechanism, Systems Biology, Natural Sciences +10

Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids

Clotilde Théry, Sebastián Amigorena, Graça Raposo et al. · Current Protocols in Cell Biology · 2006 · 5.7K citations

Biological Fluids, Cell Culture, Extracellular Microvesicles +19

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

Lydia Alvarez‐Erviti, Yiqi Seow, HaiFang Yin et al. · Nature Biotechnology · 2011 · 4.7K citations

Cell-based Drug Delivery, Nanomedicine, Systemic Injection +9

Glypican-1 identifies cancer exosomes and detects early pancreatic cancer

Sónia A. Melo, Linda B. Luecke, Christoph Kahlert et al. · Nature · 2015 · 2.8K citations · Full text

Tumor Biology, Pancreatic Cancer, Medicine +4

Standardization of sample collection, isolation and analysis methods in extracellular vesicle research

Kenneth W. Witwer, Edit I. Buzás, Lynne Bemis et al. · Journal of Extracellular Vesicles · 2013 · 2.4K citations · Full text