Discovery of N-aryl-N′-pyrimidin-4-yl ureas as irreversible L858R/T790M mutant selective epidermal growth factor receptor inhibitors

Cancer statistics, 2014

Rebecca L. Siegel, Jiemin Ma, Zhaohui Zou et al. · CA A Cancer Journal for Clinicians · 2014 · 11.5K citations · Full text

Epidemiology Of Cancer, Cancer Registration, United States +17

<i>EGFR</i> Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy

J. Guillermo Paez, Pasi A. Jänne, Jeffrey C. Lee et al. · Science · 2004 · 9.4K citations

Non-Small Cell Lung Cancer: Epidemiology, Risk Factors, Treatment, and Survivorship

Julian R. Molina, Ping Yang, Stephen D. Cassivi et al. · Mayo Clinic Proceedings · 2008 · 2.8K citations

Cancer Epidemiology, Advanced Lung Disease, Medicine +9

Novel mutant-selective EGFR kinase inhibitors against EGFR T790M

Wenjun Zhou, Dalia Ercan, Liang Chen et al. · Nature · 2009 · 988 citations · Full text

Egfr T790m, Medicine, Receptor Tyrosine Kinase +3

Discovery of a Mutant-Selective Covalent Inhibitor of EGFR that Overcomes T790M-Mediated Resistance in NSCLC

Annette O. Walter, Robert Tjin Tham Sjin, Henry J. Haringsma et al. · Cancer Discovery · 2013 · 622 citations · Full text