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Design, synthesis, biological evaluation and cocrystal structures with tubulin of chiral β -lactam bridged combretastatin A-4 analogues as potent antitumor agents

Medicinal ChemistryCocrystal StructuresDrug DiscoveryMedicineCombretastatin A-4 AnaloguesChiral β -LactamAnti-cancer AgentDrug DevelopmentPharmacologyPharmaceutical ChemistryBiomolecular Engineering