Enantioselective Friedel–Crafts C2-alkylation of 3-substituted indoles with trifluoropyruvates and cyclic <i>N</i>-sulfonyl α-ketiminoesters

Abstract

Enantioselective Friedel–Crafts C2-alkylations of 3-substituted indoles with trifluoropyruvates and cyclic α-ketiminoesters were developed, delivering indole-containing α-hydroxyesters and α-aminoesters in excellent enantioselectivities.